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Seminar: Biotransformation Processes in Micro-scale Structures

MBI Noon Seminar

Friday, February 13, 2015 12:00 PM - 1:00 PM

Fulbright Visiting Scholar Dr. Polona Žnidaršič Plazl
University of Ljubljana, Slovenia

In last two decades, microfluidic devices have been successfully applied in various fields, starting from analytics and medical diagnostics, up to industrial production of pharmaceuticals, chemicals and fuel, indicating a new paradigm in process design. In contrast, microreactor technology has found its implementation in biotechnology much later and is still mainly limited to academic research. However, due to numerous advantages, progressively more attention is attracted to the use of microfluidic devices also in bioprocesses, especially for biocatalytic synthesis. Microfluidics offer an alternative approach during the biocatalyst screening stage with extremely high throughputs, as well as in the subsequent process development stages, where reliable quantitative data, such as optimal process conditions (pH, temperature, substrate concentration etc.) and biocatalyst activity and stability at process conditions are required.

Several strategic advantages of the implementation of microstructured devices in biocatalytic processes will be discussed in this lecture. Their benefit will be illustrated by some examples studied by the Microprocess Engineering Research Group from the Faculty of Chemistry and Chemical Technology of the University of Ljubljana. Biotransformations with dissolved enzymes in two-liquid phase systems, as well as with immobilized biocatalysts – enzymes and cells - will be highlighted. Mathematical modelling of enzymatic microreactors comprising mass transfer and enzyme reaction kinetics will be presented, as well as development of intensified biocatalytic processes with the integration of downstream processing. Comparisons of microreactor-assisted processes with classical laboratory reactors will be discussed.

Additional information: http://mbi-online.org/biotransformation-processes-micro-scale-structures


Microproducts Breakthrough Institute
1110 NE Circle Blvd -- Hewlett Packard Corvallis campus
Free
Microproducts Breakthrough Institute
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