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MS Final Exam – Kenneth Squire


Wednesday, September 13, 2017 12:00 PM - 3:00 PM

Multi-Modal Biosensing with Diatom Photonic Crystal Biosilica
The need to detect trace amounts of target molecules is great, particularly when it comes to biosensing. With the early detection of a disease, the odds of the successful treatment of an individual increase significantly. To enhance the capability of biomolecular detection, we have created an optical biosensor capable of the enhancement of multi-modal optical signals. Our substrate employs diatoms, a type of algae, with unique optical properties to achieve multi-modal enhancement. Diatom shells, called frustules, are made of biosilica with quasi-periodic pores. These frustules exhibit a very large surface area and thus a large area of interaction for analytes. Additionally, the porous structure of the frustule acts as a photonic crystal capable of enhancing optical signals. Here we demonstrate the multi-modal enhancement capabilities of our biosensor through the detection of biological analytes using colorimetric shifts, surface enhanced Raman scattering and fluorescence biosensing.

Major Advisor: Alan Wang
Committee: Li-Jing Cheng
Committee: Matthew Johnston
Committee: Gregory Rorrer
GCR: Karl Schilke


Kelley Engineering Center (campus map)
1007
Calvin Hughes
1 541 737 3168
Calvin.Hughes at oregonstate.edu
Sch Elect Engr/Comp Sci
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